| Expression pattern: |
UP |
| Associated gene: |
Bcl-2, Bcl-xl |
| Associated microRNA: |
miR-1231 |
| Biological function: |
promotes BCC cell proliferation and cell viability, promotes colony formation, inhibits apoptosis, and increases anti-apoptotic protein levels |
| Molecular mechanism: |
Circ_0005795 functions as a cytoplasmic ceRNA/miRNA sponge that targets and sponges miR-1231, thereby promoting BCC progression and regulating anti-apoptotic proteins Bcl-2 and Bcl-xl. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Western Blot |
| Clinical significance: |
Circ_0005795 might serve as a promising biomarker of BCC diagnosis and a therapeutic target for BCC treatment. |
| Description: |
Circ_0005795 is up-regulated in BCC tissues and cell lines and acts as an oncogenic circRNA. It is mainly localized in the cytoplasm and promotes BCC cell proliferation and colony formation while inhibiting apoptosis by sponging miR-1231 and modulating anti-apoptotic factors such as Bcl-2 and Bcl-xl. The study proposes Circ_0005795 as a potential diagnostic biomarker and therapeutic target for BCC. |
| Confidence score: |
0.6777 |