| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
circCOL5A1 was upregulated in keloid tissues and may be related to keloid formation and development; it was proposed as a potential therapeutic target or diagnostic biomarker, but its binding miRNAs could not be predicted in this study. |
| Molecular mechanism: |
bioinformatics analysis suggested involvement in keloid-related Wnt signaling pathway; binding miRNAs were not predicted because the mature and complete sequence was not recorded in the database |
| Biological pathway or process: |
Wnt/beta-catenin (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNase R Treatment; RT-qPCR; circRNA-seq; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Potential novel therapeutic target or diagnostic biomarker for keloid patients |
| Description: |
circCOL5A1 is significantly upregulated in keloid tissues and was validated by QPCR in an expanded clinical sample set. The study links circCOL5A1 to keloid-related Wnt signaling through bioinformatics analysis, but did not experimentally define its miRNA partners or downstream molecular mechanism. |
| Confidence score: |
0.5466 |