| Expression pattern: |
UP |
| Associated gene: |
MYO6 |
| Associated microRNA: |
miR-545-3p |
| Biological function: |
Promotes CRC cell proliferation, colony formation, migration, invasion, angiogenesis and EMT; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miR-545-3p sponge to regulate MYO6 expression (ceRNA mechanism). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
High circ_0026416 expression was significantly associated with large tumor size, advanced TNM stages, and positive lymphatic metastasis. |
| Description: |
circ_0026416 is up-regulated in colorectal cancer and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion, angiogenesis and EMT while promoting apoptosis, and inhibits xenograft tumor growth, mainly by sponging miR-545-3p to relieve repression of MYO6 (circ_0026416/miR-545-3p/MYO6 axis). |
| Confidence score: |
0.7949 |