| Expression pattern: |
UP |
| Associated gene: |
ZEB1 |
| Associated microRNA: |
miR-1236-3p |
| Biological function: |
promotes proliferation, migration, invasion, EMT, tumor growth in vivo, and metastasis of LAD |
| Molecular mechanism: |
ceRNA mechanism: circRAPGEF5 sponges miR-1236-3p to upregulate ZEB1 and promote EMT/metastasis; exosomal transfer enhances metastatic ability |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circRAPGEF5 overexpression was related to lymph node metastasis; ROC analysis indicates tissue circRAPGEF5 and serum exosomal circRAPGEF5 have diagnostic ability for LAD; combined Exo-circRAPGEF5 and serum CEA improves diagnostic performance |
| Description: |
circRAPGEF5 (hsa_circ_0001681) is up-regulated in LAD tissues/cells and in exosomes. It promotes LAD proliferation, migration, invasion and EMT, at least partly by sponging miR-1236-3p to increase ZEB1 expression; exosomal circRAPGEF5 can transfer pro-metastatic signals between cells. Serum exosomal circRAPGEF5 shows diagnostic potential, especially when combined with CEA. |
| Confidence score: |
0.7954 |