| Expression pattern: |
UP |
| Associated gene: |
C-myc, Tenascin-C |
| Associated microRNA: |
miRNA-1224-5p |
| Biological function: |
promotes proliferation, migration and invasion and inhibits apoptosis in AML cells |
| Molecular mechanism: |
circRNF13 directly binds miRNA-1224-5p (miRNA sponge/target interaction) and is associated with changes in C-myc and Tenascin-C mRNA levels |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay |
| Clinical significance: |
circRNF13 is highly expressed in AML patient blood compared with healthy controls and may provide clues for diagnosis and treatment of AML |
| Description: |
circRNF13 is up-regulated in AML patient blood. Functional assays in AML cell lines indicate that circRNF13 promotes proliferation, cell-cycle progression, migration and invasion while suppressing apoptosis, and it directly interacts with miRNA-1224-5p. |
| Confidence score: |
0.6278 |