| Expression pattern: |
UP |
| Associated gene: |
CCNB1 |
| Associated microRNA: |
miR-34a-5p |
| Biological function: |
circNFIX promotes pituitary adenoma cell invasion, migration, proliferation and tumor formation; circNFIX silencing inhibits these phenotypes. |
| Molecular mechanism: |
circNFIX acts as a ceRNA/miRNA sponge for miR-34a-5p, relieving suppression of CCNB1 and thereby promoting pituitary adenoma progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Transwell Assay; CCK8; Colony Formation Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
High circNFIX expression is related to high Knosp grade and poor prognosis, suggesting circNFIX is a potential biomarker and treatment target for pituitary adenomas. |
| Description: |
circNFIX (hsa_circ_0005660) is up-regulated in invasive pituitary adenomas and promotes invasion, migration, proliferation, and tumor formation. Mechanistically, it sponges miR-34a-5p to up-regulate CCNB1, forming a circNFIX/miR-34a-5p/CCNB1 axis. High circNFIX expression is associated with high Knosp grade and poor prognosis, suggesting potential biomarker and therapeutic relevance. |
| Confidence score: |
0.7126 |