| Expression pattern: |
DN |
| Associated gene: |
KLF5 |
| Associated microRNA: |
miR-153-3p |
| Biological function: |
CircATRNL1 protects against OA-associated chondrocyte injury by attenuating IL-1beta-induced chondrocyte apoptosis, inflammatory responses, and extracellular matrix degradation. |
| Molecular mechanism: |
CircATRNL1 acts through a ceRNA-like mechanism by targeting miR-153-3p, thereby regulating the miR-153-3p/KLF5 axis in OA chondrocytes. |
| Biological pathway or process: |
apoptosis (inhibits); inflammation (inhibits); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
CircATRNL1 may be a therapeutic target or promising alternative therapy for OA. |
| Description: |
CircATRNL1 is down-regulated in OA cartilage and IL-1beta-treated human chondrocytes. Its overexpression protects chondrocytes by reducing apoptosis, inflammatory responses, and ECM degradation, likely through regulation of the miR-153-3p/KLF5 axis. The study suggests circATRNL1 as a potential therapeutic target for OA. |
| Confidence score: |
0.7291 |