circRNA basic information
circBase ID: hsa_circ_0002360
Name: hsa_circ_RUNX1
Synonym: circRUNX1
Host Gene: RUNX1
Genomic location(hg19): chr21:36206706-36231875:-
Genomic location(hg38): chr21:34834409-34859578:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005029
MONDO name: essential thrombocythemia
Disease details: essential thrombocythemia
Disease DO ID:
 2224
Disease MeSH ID:
 D013920
Disease NCIt ID:
 C3407
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow tissues; bone marrow-derived exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: Smad3, Phosphatidylinositol 3-Kinase (PI3K), protein kinase B (Akt), Janus kinase (JAK), Signal transducer and activator of transcription 3 (STAT3), TGF-beta, c-Met, WNT
Associated microRNA: miR-34b-5p, miR-29b-1-5p, miR-185-3p, miR-210-3p, miR-217
Biological function: Down-regulated in bone marrow-derived exosomes from ET patients; predicted to regulate cell proliferation and apoptosis through miR-29b-1-5p, miR-34b-5p and downstream functional genes/signaling pathways.
Molecular mechanism: Predicted circRNA-miRNA-mRNA ceRNA network in which circRUNX1 targets miR-29b-1-5p and miR-34b-5p, potentially regulating genes and pathways including Smad3, PI3K/Akt, JAK/STAT3, TGF-beta, c-Met and WNT signaling.
Biological pathway or process:

ceRNA regulation (other); proliferation (other); apoptosis (other); PI3K/AKT (other); JAK/STAT (other); TGF-beta/SMAD (other); Wnt/beta-catenin (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential basis for circRNA-based ET diagnosis and treatment.
Description:

hsa_circ_0002360/circRUNX1 is down-regulated in bone marrow-derived exosomes from ET patients and was experimentally validated at the expression and circular-structure levels. The predicted circRUNX1 miRNA/mRNA network includes miR-29b-1-5p and miR-34b-5p, suggesting possible involvement in proliferation, apoptosis, PI3K/Akt, JAK/STAT, TGF-beta, WNT and c-Met-related signaling during ET pathogenesis.
Confidence score:

0.5841
Other information
Title:

Differential expression of circular RNAs in bone marrow-derived exosomes from essential thrombocythemia patients.

Journal: Cell biology international
Published: 2021
PubMed ID: 33325145
Study type:

combined biological and clinical study
Data availability: available from the corresponding author on reasonable request
Code availability: -