| Expression pattern: |
UP |
| Associated gene: |
MYOCD, KLF5, TGFBR2, ACE |
| Associated microRNA: |
hsa-miR-145-5p |
| Biological function: |
hsa_circ_0037897 is up-regulated in essential hypertension, may be a risk factor for EH, has diagnostic biomarker value, and may participate in EH development by acting as a sponge for hsa-miR-145-5p. |
| Molecular mechanism: |
Predicted ceRNA mechanism in which hsa_circ_0037897 acts as a sponge for hsa-miR-145-5p within a circRNA-miRNA-mRNA network; KEGG analysis of hsa-miR-145-5p targets highlighted the Wnt signaling pathway. |
| Biological pathway or process: |
ceRNA regulation (promotes); Wnt/beta-catenin (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High expression of hsa_circ_0037897 may be a risk factor for EH and has certain diagnostic value; AUC was 0.656 alone and increased when combined with hsa-miR-145-5p, BMI and smoking. |
| Description: |
This case-control study found that hsa_circ_0037897 is significantly up-regulated in peripheral blood from patients with essential hypertension. The authors propose that hsa_circ_0037897 may act as a sponge for hsa-miR-145-5p in a circRNA-miRNA-mRNA network and may serve as a risk factor and diagnostic biomarker for EH. |
| Confidence score: |
0.5047 |