circRNA basic information
circBase ID: hsa_circ_0025033
Name: hsa_circ_FOXM1
Synonym: circ_0025033
Host Gene: FOXM1
Genomic location(hg19): chr12:2966846-2983691:-
Genomic location(hg38): chr12:2857680-2874525:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008170
MONDO name: ovarian cancer
Disease details: ovarian cancer
Disease DO ID:
 2394
Disease MeSH ID:
 D010051
Disease NCIt ID:
 C7431
Disease ICD11 ID:
 685124533
Disease OMIM ID:
 167000
Species: Human
Species details: Homo sapiens
Tissue specimen:

OC tumor tissues; matched paracancer tissues; excised tumor tissues
Cell lines:

SKOV3; A2780; IOSE80
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: LSM4, PKM2
Associated microRNA: miR-184
Biological function: Circ_0025033 promotes OC cell colony formation, migration, invasion, glycolysis metabolism and tumor growth; circ_0025033 knockdown suppresses these malignant phenotypes.
Molecular mechanism: Circ_0025033 functions as a ceRNA that targets miR-184 to positively regulate LSM4 expression, thereby promoting OC progression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry)
Clinical significance:

Circ_0025033 might be a vital biomarker in diagnosis and treatment of OC.
Description:

Circ_0025033 is up-regulated in ovarian cancer tissues and cell lines. It promotes colony formation, migration, invasion, glycolysis metabolism and xenograft tumor growth by acting as a ceRNA for miR-184 to increase LSM4 expression, suggesting potential diagnostic or therapeutic relevance.
Confidence score:

0.7126
Other information
Title:

Circ_0025033 promotes the progression of ovarian cancer by activating the expression of LSM4 via targeting miR-184.

Journal: Pathology, research and practice
Published: 2021
PubMed ID: 33285422
Study type:

combined biological and clinical study
Data availability: Supplementary material related to this article can be found, in the online version, at doi:https://doi.org/10.1016/j.prp.2020.153275
Code availability: -