| Expression pattern: |
UP |
| Associated gene: |
MYC |
| Associated microRNA: |
miR-758-3p |
| Biological function: |
promotes AML progression, enhances cell proliferation, promotes cell cycle progression, and inhibits apoptosis |
| Molecular mechanism: |
circ_0002483 targets miR-758-3p and indirectly regulates MYC through the circ_0002483/miR-758-3p/MYC axis |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis |
| Clinical significance: |
circ_0002483 is highly expressed in bone marrow tissues from AML patients and may provide a new target for AML treatment |
| Description: |
Hsa_circ_0002483/circ_0002483 is up-regulated in AML bone marrow samples and AML cell lines. Functionally, circ_0002483 promotes AML cell proliferation and cell cycle progression while inhibiting apoptosis. Mechanistically, it regulates the miR-758-3p/MYC axis, suggesting a potential therapeutic target in AML. |
| Confidence score: |
0.8111 |