| Expression pattern: |
UP |
| Associated gene: |
NLRP3 |
| Associated microRNA: |
miR-942 |
| Biological function: |
circ_0001438 inhibits proliferation, migration and invasion, and promotes apoptosis and inflammatory responses in HTR-8/Svneo trophoblast cells, contributing to villous trophoblast dysfunction in preeclampsia. |
| Molecular mechanism: |
circ_0001438 targets miR-942 and negatively regulates miR-942 expression, thereby activating NLRP3 expression through the circ_0001438/miR-942/NLRP3 regulatory network. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); inflammation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot |
| Clinical significance: |
circ_0001438 may be a useful biomarker and significant therapeutic biomarker linked to the pathogenesis of PE. |
| Description: |
circ_0001438 is up-regulated in placental tissues from patients with preeclampsia. In HTR-8/Svneo trophoblast cells, circ_0001438 suppresses proliferation, migration and invasion while promoting apoptosis and inflammatory responses. Mechanistically, it acts through the circ_0001438/miR-942/NLRP3 regulatory network and may serve as a therapeutic biomarker for PE. |
| Confidence score: |
0.6536 |