| Expression pattern: |
UP |
| Associated gene: |
E2F3, PCNA |
| Associated microRNA: |
miR-4295 |
| Biological function: |
Promotes NSCLC cell proliferation, PCNA expression, glycolysis/glucose consumption, and tumor growth in vivo. |
| Molecular mechanism: |
Circ_0016760 acts as a ceRNA/miRNA sponge for miR-4295, thereby upregulating E2F3 expression and promoting proliferation and glycolysis in NSCLC cells. |
| Biological pathway or process: |
proliferation (promotes); glycolysis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Western Blot; In Vivo Animal Model; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
Provides a novel potential target for NSCLC treatment and a new perspective for the diagnosis and treatment of NSCLC. |
| Description: |
Circ_0016760 is upregulated in NSCLC tissues and cell lines. It promotes NSCLC cell proliferation, PCNA expression, glycolysis/glucose consumption, and xenograft tumor growth by sponging miR-4295 to increase E2F3 expression. The study proposes circ_0016760 as a potential target for NSCLC diagnosis and treatment. |
| Confidence score: |
0.6479 |