circRNA basic information
circBase ID: hsa_circ_0004458
Name: hsa_circ_PSD3
Synonym: circRNA pleckstrin and Sec7 domain containing 3
Host Gene: PSD3
Genomic location(hg19): chr8:18656804-18662408:-
Genomic location(hg38): chr8:18799294-18804898:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid carcinoma
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PTC tissues; matching paracancerous tissues; PTC tumor tissues; adjacent normal tissues; xenograft tumor tissues
Cell lines:

Nthy-ori3-1; TPC-1; CGTH-W3; IHH-4; SW579
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: HEMGN, HEMGN mRNA, PI3K, Akt, p-PI3K, p-Akt, Cyclin D1, CDK4, snail, E-cadherin
Associated microRNA: miR-637
Biological function: Circ_PSD3 promotes cell cycle progression, proliferation, migration, invasion, metastasis and in vivo tumor growth, and inhibits apoptosis of PTC cells.
Molecular mechanism: Circ_PSD3 functions as a ceRNA/miRNA sponge for miR-637, thereby up-regulating HEMGN and enhancing PI3K/Akt signaling activity.
Biological pathway or process:

PI3K/AKT (promotes); cell cycle (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; MTT; Transwell Assay; Luciferase Reporter Assay; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

Circ_PSD3/miR-637/HEMGN signaling axis might be a potential target for PTC therapy.
Description:

Circ_PSD3 is up-regulated in PTC tissues and cell lines and acts as an oncogenic circRNA. It promotes PTC cell cycle progression, proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_PSD3 sponges miR-637 to up-regulate HEMGN and activate PI3K/Akt signaling, suggesting the circ_PSD3/miR-637/HEMGN axis as a potential therapeutic target.
Confidence score:

0.7595
Other information
Title:

Circ_PSD3 promotes the progression of papillary thyroid carcinoma via the miR-637/HEMGN axis.

Journal: Life sciences
Published: 2021
PubMed ID: 33203523
Study type:

combined biological and clinical study
Data availability: Supplementary data to this article can be found online at https://doi. org/10.1016/j.lfs.2020.118622.
Code availability: -