| Expression pattern: |
UP |
| Associated gene: |
YWHAZ, c-myc, Bcl-2, Bax, MMP9 |
| Associated microRNA: |
miR-665 |
| Biological function: |
circ-PRRX1 promotes GC cell viability/proliferation, migration, invasion, metastasis-related features, and tumor growth, and suppresses apoptosis; circ-PRRX1 knockdown inhibits these malignant phenotypes and promotes apoptosis. |
| Molecular mechanism: |
circ-PRRX1 functions as a miR-665 sponge to regulate YWHAZ expression in a circ-PRRX1/miR-665/YWHAZ ceRNA axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ-PRRX1 is upregulated in GC tissues and may provide a theoretical basis for GC therapy. |
| Description: |
In gastric carcinoma, circ-PRRX1/hsa_circ_0004370 is upregulated in tumor tissues and GC cell lines. It promotes malignant progression by enhancing proliferation, migration, invasion, and in vivo tumor growth while inhibiting apoptosis. Mechanistically, circ-PRRX1 acts as a miR-665 sponge to regulate YWHAZ expression through a circ-PRRX1/miR-665/YWHAZ axis. |
| Confidence score: |
0.6829 |