| Expression pattern: |
DN |
| Associated gene: |
TGFBR2, PI3K/Akt pathway |
| Associated microRNA: |
miR-107 |
| Biological function: |
Suppresses NPC cell proliferation, migration, invasion, EMT, tumor growth, and lung metastasis; promotes apoptosis; acts as a tumor suppressive factor. |
| Molecular mechanism: |
circTGFBR2 acts as a ceRNA/miR-107 sponge, upregulates TGFBR2 expression, inhibits PI3K/Akt pathway activity, and suppresses NPC progression. |
| Biological pathway or process: |
PI3K/AKT (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
H
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; ISH (In Situ Hybridization); FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; IHC (Immunohistochemistry); IF (Immunofluorescence); Western Blot; In Vivo Animal Model; H&E Staining; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circTGFBR2 overexpression correlated with favorable prognosis in NPC; low circTGFBR2 levels were associated with worse overall survival and metastasis-free survival; circTGFBR2 may serve as a promising diagnostic biomarker and therapeutic target. |
| Description: |
circTGFBR2 is a TGFBR2-derived circRNA downregulated in NPC tissues and cells. It functions as a tumor suppressor by sponging miR-107, increasing TGFBR2 expression, inhibiting PI3K/Akt activity and EMT, and suppressing proliferation, migration, invasion, tumor growth, and metastasis. Higher circTGFBR2 expression is associated with favorable NPC prognosis. |
| Confidence score: |
0.8648 |