| Expression pattern: |
DN |
| Associated gene: |
KLF2 |
| Associated microRNA: |
miR-1206 |
| Biological function: |
Suppresses lung cancer cell growth, angiopoiesis, migration, and invasion; induces apoptosis; suppresses tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0043256 sponges miR-1206 to upregulate KLF2 |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); angiogenesis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Luciferase Reporter Assay; Transfection; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Tube Formation Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
circ_0043256 is down-regulated in lung cancer and acts as a tumor suppressor. It mainly localizes to the cytoplasm and inhibits malignant phenotypes by sponging miR-1206 to increase KLF2 expression, suppressing tumor growth in vitro and in vivo. |
| Confidence score: |
0.7229 |