| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-198 |
| Biological function: |
promotes proliferation, migration and colony formation of breast cancer cells; promotes tumor growth in vivo |
| Molecular mechanism: |
acts as a competing endogenous RNA to sponge miR-198 |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; Actinomycin D / DRB Stability Assay; FISH / smFISH; RNase R Treatment; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; MTT; Transwell Assay; Wound Healing Assay; Colony Formation Assay; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
potential biomarker as a diagnostic and therapeutic target |
| Description: |
circPTCD3 (hsa_circ_0055478), derived from PTCD3 exons 3-9, is up-regulated in breast cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes breast cancer cell proliferation and migration and enhances xenograft tumor growth by acting as a ceRNA that sponges miR-198. |
| Confidence score: |
0.8275 |