| Expression pattern: |
UP |
| Associated gene: |
JAG1, Ago2, SEC61A1 |
| Associated microRNA: |
miR-129-5p |
| Biological function: |
Circ_0007841 promotes MM cell proliferation, metastasis, BTZ chemoresistance and tumor growth, while inhibiting apoptosis; circ_0007841 knockdown suppresses these malignant phenotypes and enhances apoptosis. |
| Molecular mechanism: |
Circ_0007841 acts as a ceRNA by sponging miR-129-5p, thereby positively regulating JAG1 expression and promoting MM progression and BTZ resistance. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); chemoresistance (promotes); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0007841 expression is associated with lower survival rate and correlated with ISS stage and Durie-Salmon stage in MM patients; circ_0007841 might serve as a potential therapeutic target. |
| Description: |
Circ_0007841 is up-regulated in MM bone marrow aspirates and cell lines, and high expression is associated with poorer survival. Functionally, circ_0007841 acts as an oncogenic circRNA that promotes proliferation, metastasis, tumor growth and BTZ resistance while suppressing apoptosis. Mechanistically, it sponges miR-129-5p to increase JAG1 expression, forming a circ_0007841/miR-129-5p/JAG1 regulatory axis. |
| Confidence score: |
0.8593 |