| Expression pattern: |
UP |
| Associated gene: |
CTNND1 |
| Associated microRNA: |
miR-1271-5p |
| Biological function: |
Promotes EC cell proliferation, migration, invasion, cell cycle progression, metastasis-related protein expression and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0000043 acts as a ceRNA/molecular sponge for miR-1271-5p to positively regulate CTNND1 expression, thereby promoting EC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); cell cycle (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; In Vivo Animal Model |
| Clinical significance: |
May provide a promising circRNA-targeted therapy and new insights for EC treatment. |
| Description: |
circ_0000043 is up-regulated in endometrial carcinoma tissues and cell lines. It promotes EC progression by sponging miR-1271-5p and thereby increasing CTNND1 expression, leading to enhanced proliferation, migration, invasion, cell cycle progression and xenograft tumor growth, while suppressing apoptosis. The circ_0000043/miR-1271-5p/CTNND1 axis is proposed as a potential therapeutic target for EC. |
| Confidence score: |
0.742 |