| Expression pattern: |
UP |
| Associated gene: |
TDO2, AGO2 |
| Associated microRNA: |
miR-4738-3p |
| Biological function: |
promotes HCC cell migration, invasion, and proliferation; promotes tumorigenesis and metastasis |
| Molecular mechanism: |
acts as a miR-4738-3p sponge to relieve repression of TDO2 (ceRNA mechanism) |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Sanger Sequencing; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; Western Blot |
| Clinical significance: |
High circZNF566 expression in HCC tissues was positively correlated with clinicopathological features and poor prognosis; may serve as a novel diagnostic marker and prognostic indicator |
| Description: |
circZNF566 is up-regulated in HCC and promotes proliferation, migration, invasion, tumorigenesis and metastasis. It functions mainly as a ceRNA by sponging miR-4738-3p, thereby relieving repression of TDO2 and driving HCC progression; high circZNF566 is associated with poorer survival. |
| Confidence score: |
0.8921 |