| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
circZRANB1 is upregulated in psoriasis lesional skin and showed potential as a diagnostic biomarker for discriminating psoriasis from AD. |
| Molecular mechanism: |
circZRANB1 was upregulated independently of the linear transcript in psoriasis; no functional molecular mechanism was experimentally established. |
| Biological pathway or process: |
other pathway/process (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circZRANB1 showed strong potential as a diagnostic biomarker for classifying psoriasis lesional skin and AD lesional skin, with an area under the curve of 0.89. |
| Description: |
circZRANB1 was identified as an upregulated circRNA in psoriasis lesional skin and was more abundant in psoriasis lesional skin than AD lesional skin. It showed strong diagnostic biomarker potential for distinguishing psoriasis from AD, while Sanger sequencing confirmed its back-splicing junction and circularity. |
| Confidence score: |
0.6238 |