| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-548c-3p, miR-587, miR-4739, miR-125a-3p, miR-297 |
| Biological function: |
unknown |
| Molecular mechanism: |
Predicted ceRNA/miRNA sponge mechanism (not experimentally validated). |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Survival Analysis |
| Clinical significance: |
Diagnostic biomarker potential (AUC 0.773; 64% sensitivity; 82% specificity) and prognostic association (high expression associated with longer OS); associated with differentiation, TNM stage and lymphatic metastasis. |
| Description: |
hsa_circ_0005556 is significantly down-regulated in gastric cancer tissues and shows diagnostic potential (ROC AUC 0.773). Higher tumor hsa_circ_0005556 levels are associated with longer overall survival, and its expression correlates with differentiation, TNM stage, and lymphatic metastasis. A miRNA-sponge (ceRNA) role is proposed based on bioinformatic prediction but not experimentally validated. |
| Confidence score: |
0.6355 |