| Expression pattern: |
UP |
| Associated gene: |
RAB23 |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
Promotes thyroid cancer cell growth, proliferation, migration, invasion, tumorigenesis and metastasis. |
| Molecular mechanism: |
circHIPK3 acts as a miR-338-3p sponge and upregulates RAB23 expression in thyroid cancer. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circHIPK3 could be a promising therapeutic strategy for TC patients. |
| Description: |
circHIPK3 is up-regulated in thyroid cancer tissues and cell lines. Functional knockdown experiments indicate that circHIPK3 promotes TC cell growth, migration and invasion. Mechanistically, the study proposes that circHIPK3 promotes tumorigenesis and invasiveness through the miR-338-3p/RAB23 regulatory axis. |
| Confidence score: |
0.6777 |