| Expression pattern: |
UP |
| Associated gene: |
TIP60, NR2F6 |
| Associated microRNA: |
- |
| Biological function: |
promotes HCC growth and metastasis; promotes proliferation, migration and invasion; promotes survival and inhibits apoptosis |
| Molecular mechanism: |
circRHOT1 recruits TIP60 to the NR2F6 promoter to initiate NR2F6 transcription (NuA4 complex-related chromatin regulation). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); Notch (inhibits) |
| Detected method: |
Q
B
H
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Northern Blot; ISH (In Situ Hybridization); FISH / smFISH; Back-Splice Junction PCR / divergent primers PCR; RNA-seq; Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; RIP (RNA Immunoprecipitation); RNA Pull-Down; ChIP / ChIP-seq; Western Blot; In Vivo Animal Model; Survival Analysis; Nuclear-Cytoplasmic Fractionation |
| Clinical significance: |
high circRHOT1 expression predicts poor prognosis in HCC patients |
| Description: |
circRHOT1 is up-regulated in HCC tissues and its high level is associated with poor prognosis. Functionally, it promotes HCC cell proliferation, migration/invasion, tumor growth and metastasis, partly by recruiting TIP60 to the NR2F6 promoter to activate NR2F6 transcription, with reported involvement of NOTCH2 signaling downstream. |
| Confidence score: |
0.8129 |