| Expression pattern: |
UP |
| Associated gene: |
Wnt5a, ELK1, ANXA2R, AGO2 |
| Associated microRNA: |
miR-139-3p |
| Biological function: |
circ-0038718 exerts oncogenic properties in HCC by promoting cell proliferation, colony formation, migration, invasion and xenograft tumor development. |
| Molecular mechanism: |
circ-0038718 functions as a miRNA sponge for miR-139-3p and promotes Wnt5a, ELK1 and ANXA2R expression, thereby promoting HCC progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; RNase R Treatment; Actinomycin D / DRB Stability Assay; Back-Splice Junction PCR / divergent primers PCR; FISH / smFISH; Survival Analysis; Cohort Study; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot |
| Clinical significance: |
High circ-0038718 expression was associated with tumor size, vascular invasion, TNM stage, poor overall survival and disease-free survival, and circ-0038718 could be a potential prognostic biomarker for HCC patients. |
| Description: |
circ-0038718 is an IL4R-derived human circRNA upregulated in HCC tissues and cell lines. It acts as an oncogenic circRNA that promotes HCC proliferation, migration, invasion and xenograft tumor growth, at least partly by sponging miR-139-3p and increasing Wnt5a, ELK1 and ANXA2R expression. High circ-0038718 expression is associated with malignant clinicopathologic features and poor OS/DFS, suggesting prognostic and therapeutic relevance. |
| Confidence score: |
0.8823 |