| Expression pattern: |
UP |
| Associated gene: |
CYP51A1 |
| Associated microRNA: |
miR-3926 |
| Biological function: |
May regulate CYP51A1 expression and participate in endometriosis-related follicular development; predicted to target miR-3926. |
| Molecular mechanism: |
Predicted ceRNA interaction with miR-3926 and possible regulation of host gene CYP51A1 expression. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other); inflammation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Potential diagnostic and therapeutic target for endometriosis-associated infertility. |
| Description: |
hsa_circ_0007299 was up-regulated in cumulus cells from endometriosis-associated infertility patients and validated by qRT-PCR. It is spliced from CYP51A1 and may regulate CYP51A1 expression and follicular development, with miR-3926 predicted as a target miRNA. |
| Confidence score: |
0.5994 |