| Expression pattern: |
UP |
| Associated gene: |
TGFBR1, HMGB1, HMGCS1 |
| Associated microRNA: |
let-7a-5p, let-7c-5p, let-7g-5p, let-7i-5p, hsa-miR-129-5p |
| Biological function: |
May be involved in cumulus cell proliferation and apoptosis and abnormal follicular development in endometriosis-associated infertility. |
| Molecular mechanism: |
Predicted ceRNA mechanism through let-7g-5p/TGFBR1 and miR-129-5p/HMGB1 axes. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (other); apoptosis (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Potential diagnostic and therapeutic target for endometriosis-associated infertility. |
| Description: |
hsa_circ_0072391 was up-regulated in cumulus cells from endometriosis-associated infertility patients and validated by qRT-PCR. The study predicts that it may regulate cumulus cell proliferation and apoptosis through ceRNA axes involving let-7g-5p/TGFBR1 or miR-129-5p/HMGB1. |
| Confidence score: |
0.5994 |