| Expression pattern: |
UP |
| Associated gene: |
Capn4, Wnt/beta-catenin signaling pathway |
| Associated microRNA: |
miR-1271 |
| Biological function: |
promotes cell proliferation and invasion; inhibits apoptosis; activates Capn4/Wnt/beta-catenin signaling pathway |
| Molecular mechanism: |
circ-ABCB10 directly binds (sponges) miR-1271, relieving miR-1271-mediated repression and increasing Capn4, thereby activating Wnt/beta-catenin signaling |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot |
| Clinical significance: |
circ-ABCB10 correlates with deteriorated clinical features and poor prognosis in patients with EOC |
| Description: |
In epithelial ovarian cancer cell models, circ-ABCB10 is up-regulated and promotes proliferation and invasion while inhibiting apoptosis. Mechanistically, circ-ABCB10 directly binds and negatively regulates miR-1271, leading to increased Capn4 and activation of Wnt/beta-catenin signaling. |
| Confidence score: |
0.6152 |