circRNA basic information
circBase ID: -
Name: hsa_circ_MAP2K4
Synonym: hsa_circRNA_101981
Host Gene: MAP2K4
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

prostate cancer tissue; nonmalignant prostate tissue
Cell lines:

LNCaP; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-145-5p
Biological function: -
Molecular mechanism: miR-145-5P regulates hsa_circRNA_101981; interaction confirmed by dual-luciferase reporter assay.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circRNA_101981 (host gene MAP2K4) is down-regulated in prostate cancer tissue but up-regulated upon miR-145 overexpression in LNCaP cells. Its interaction with hsa-miR-145-5p was supported by bioinformatic prediction and confirmed by dual-luciferase reporter assay.
Confidence score:

0.5922
Other information
Title:

MiR-145 affected the circular RNA expression in prostate cancer LNCaP cells.

Journal: Journal of cellular biochemistry
Published: 2018
PubMed ID: 30136305
Study type:

combined biological and clinical study
Data availability: -
Code availability: -