| Expression pattern: |
DN |
| Associated gene: |
PRKCD / protein kinase C, delta |
| Associated microRNA: |
miR-615-3p |
| Biological function: |
circITCH inhibits MM cell proliferation, promotes apoptosis of BTZ-resistant MM cells, and enhances sensitivity to bortezomib. |
| Molecular mechanism: |
circITCH functions as a miRNA sponge for miR-615-3p and regulates PRKCD expression, thereby enhancing bortezomib sensitivity in MM cells. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); chemoresistance (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Reduced expression of circITCH is indicative of poor prognosis in MM patients; high circITCH expression is associated with longer overall survival. |
| Description: |
circITCH is downregulated in multiple myeloma bone marrow specimens, MM cell lines, and bortezomib-resistant MM cells. Higher circITCH expression predicts longer overall survival, and circITCH overexpression enhances bortezomib sensitivity by promoting apoptosis and suppressing viability through the miR-615-3p/PRKCD axis. |
| Confidence score: |
0.7537 |