circRNA basic information
circBase ID: hsa_circ_0043273
Name: hsa_circ_TADA2A
Synonym: -
Host Gene: TADA2A
Genomic location(hg19): chr17:35771355-35800763:+
Genomic location(hg38): chr17:37411268-37440662:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma exosome
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: KLF14
Associated microRNA: miR-520f, miR-455-3p, miR-129-5p, miR-374a-3p
Biological function: -
Molecular mechanism: ceRNA mechanism (miRNA sponge)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

candidate biomarker for the diagnosis of LUAD
Description:

circ-0043273 (circTADA2A) is upregulated in LUAD patient plasma exosomes and was validated by RT-qPCR. It is proposed as a candidate non-invasive diagnostic biomarker; prior studies cited suggest it can function as a ceRNA by sponging several miRNAs.
Confidence score:

0.5135
Other information
Title:

Identification of a Plasma Exosomal lncRNA- and circRNA-Based ceRNA Regulatory Network in Patients With Lung Adenocarcinoma.

Journal: The clinical respiratory journal
Published: 2024
PubMed ID: 39428538
Study type:

combined biological and clinical study
Data availability: The data in this study can be obtained under reasonable conditions by contacting Dr. Wangyu Zhu (email: zhuwangyu24@sina.cn).
Code availability: -