| Expression pattern: |
DN |
| Associated gene: |
HAMP, JAK2/STAT3/AKT signaling pathway |
| Associated microRNA: |
miR-184 |
| Biological function: |
Circ_0004913 acts as a tumor suppressor in HCC; its overexpression inhibits cell proliferation, colony formation, migration, invasion, EMT, glycolysis, and tumor growth in vivo. |
| Molecular mechanism: |
Circ_0004913 sponges miR-184 to upregulate HAMP and inactivate the JAK2/STAT3/AKT signaling pathway. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); glycolysis (inhibits); JAK/STAT (inhibits); PI3K/AKT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Circ_0004913 might be a potential molecular marker for the treatment of HCC. |
| Description: |
Circ_0004913 is downregulated in HCC tissues and cell lines and functions as an antitumor circRNA. It suppresses HCC proliferation, migration, invasion, EMT, glycolysis, and xenograft tumor growth by sponging miR-184, increasing HAMP expression, and inactivating the JAK2/STAT3/AKT pathway. |
| Confidence score: |
0.7519 |