| Expression pattern: |
UP |
| Associated gene: |
NRBP1, Bax, Bcl-2, MMP2, MMP9 |
| Associated microRNA: |
miR-328-3p |
| Biological function: |
circ_0020394 promotes bladder cancer cell viability, migration, invasion and glycolysis, inhibits apoptosis, and attenuates the antitumor effect of puerarin. |
| Molecular mechanism: |
circ_0020394 acts as a miR-328-3p sponge to increase NRBP1 expression in puerarin-treated bladder cancer cells. |
| Biological pathway or process: |
apoptosis (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (other); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
This study identifies circ_0020394 as a pro-tumor circRNA in bladder cancer cells that counteracts puerarin-induced suppression of viability, migration, invasion and glycolysis and puerarin-induced apoptosis. Mechanistically, circ_0020394 sponges miR-328-3p to increase NRBP1 expression, forming a circ_0020394/miR-328-3p/NRBP1 axis involved in the antitumor response to puerarin. |
| Confidence score: |
0.5627 |