circRNA basic information
circBase ID: hsa_circ_0007367
Name: -
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 114
DO name: heart disease
Disease details: extracorporeal membrane oxygenation
Species: human
Species details: human
Sample type: PDX
Sample type details: Pulmonary Microvascular Endothelial Cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: upregulation of hsa_circ_0007367 stabilized the expressions of endothelial tight junction markers zonula occludens- (ZO-) 1 and occludin
Molecular mechanism: upregulation of hsa_circ_0007367 stabilized the expressions of endothelial tight junction markers zonula occludens- (ZO-) 1 and occludin, followed by modulating the endothelial nitric oxide synthases (eNOS) activity and inhibiting the NF-¦ĘB signaling pathway.
Survival: -
Supported No.:
 2
Description:

The modification of pulsatility contributes to microcirculatory perfusion and endothelial integrity during ECMO. The expression of hsa_circ_0007367 plays a pivotal role in this protective mechanism.
Other information
Title:

Arterial Pulsatility Augments Microcirculatory Perfusion and Maintains the Endothelial Integrity during Extracorporeal Membrane Oxygenation via hsa_circ_0007367 Upregulation in a Canine Model with Cardiac Arrest.

Journal: Oxid Med Cell Longev
Published: 2022/3/1
PubMed ID: 35222790