circRNA basic information
circBase ID: hsa_circ_0057576
Name: hsa_circ_HECW2
Synonym: -
Host Gene: HECW2
Genomic location(hg19): chr2:197118643-197143386:-
Genomic location(hg38): chr2:196253919-196278662:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005010
MONDO name: coronary artery disorder
Disease details: coronary artery disease
Disease DO ID:
 3393
Disease MeSH ID:
 D003324
Disease NCIt ID:
 C26732
Disease ICD11 ID:
 1059873720
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TRPM3
Associated microRNA: hsa-miR-130a-3p
Biological function: Promotes TRPM3 expression by inhibiting (sponging) hsa-miR-130a-3p in CAD.
Molecular mechanism: ceRNA network prediction involving hsa-miR-130a-3p and TRPM3.
Biological pathway or process:

ceRNA regulation (promotes)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0057576 is up-regulated in CAD plasma and was computationally linked to a hsa-miR-130a-3p/TRPM3 ceRNA network, implying a miRNA sponge role that promotes TRPM3 expression.
Confidence score:

0.1768
Other information
Title:

Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.

Journal: Oncotarget
Published: 2017
PubMed ID: 28947970
Study type:

combined biological and clinical study
Data availability: -
Code availability: -