circRNA basic information
circBase ID: hsa_circ_0049613
Name: hsa_circ_MAST1
Synonym: hsa_circRNA_102459
Host Gene: MAST1
Genomic location(hg19): chr19:12962747-12963209:+
Genomic location(hg38): chr19:12851933-12852395:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; non-tumor liver tissues; serum
Cell lines:

HepG2; SK-HepG1; Huh7; HCCLM3; L02; HEK293T; 293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CTNND1
Associated microRNA: miR-1299
Biological function: Promotes HCC cell proliferation, cell cycle progression, migration and invasion, and promotes tumor growth in vivo.
Molecular mechanism: Acts as a miRNA sponge (ceRNA) for miR-1299, thereby protecting/stabilizing CTNND1 expression and promoting tumorigenic features.
Biological pathway or process:

proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
H
M
Validation methods:

Microarray; RT-qPCR; FISH / smFISH; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry)
Clinical significance:

circMAST1 may serve as a novel biomarker for HCC.
Description:

circMAST1 is up-regulated in hepatocellular carcinoma and acts as an oncogenic circRNA. It promotes proliferation, cell-cycle progression, migration/invasion, and tumor growth by sponging miR-1299 and relieving miR-1299-mediated suppression of CTNND1 (circMAST1/miR-1299/CTNND1 axis).
Confidence score:

0.807
Other information
Title:

The circular RNA circMAST1 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-1299 and regulating CTNND1 expression.

Journal: Cell death & disease
Published: 2020
PubMed ID: 32393764
Study type:

combined biological and clinical study
Data availability: GSE78520; online-only Supplement Data (Additional file 6: Supplementary Table S5; Additional file 7: Supplementary Fig. S1A)
Code availability: -