circRNA basic information
circBase ID: hsa_circ_0081111
Name: hsa_circ_COL1A2
Synonym: circ-COL1A2
Host Gene: COL1A2
Genomic location(hg19): chr7:94037494-94058742:+
Genomic location(hg38): chr7:94408182-94429430:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent non-tumor tissues; cancerous and adjacent normal tissues; brain metastasis cancer tissue samples; primary lung cancer tissues; xenograft tumor tissues
Cell lines:

H1975; A549; H1299; BEAS-2B
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: IGF2BP2, Slug mRNA
Associated microRNA: -
Biological function: Promotes proliferation, invasion, EMT, metastasis-related malignant progression, xenograft tumor growth, and MMP9 expression in NSCLC.
Molecular mechanism: Hsa_circ_0081111 interacts with the RNA-binding protein IGF2BP2 and stabilizes Slug mRNA, increasing Slug expression and driving NSCLC proliferation, invasion, and EMT.
Biological pathway or process:

proliferation (promotes); invasion (promotes); EMT (promotes); metastasis (promotes); mRNA stability (promotes); other pathway/process (promotes)
Detected method:
Q
S
Validation methods:

RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; Clinical Sample Validation; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; CCK8; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); IF (Immunofluorescence); Nuclear-Cytoplasmic Fractionation; Western Blot; Bioinformatics Analysis
Clinical significance:

High expression is positively correlated with TNM stage and lymph node metastasis; hsa_circ_0081111 has potential as a diagnostic and therapeutic target for NSCLC.
Description:

Hsa_circ_0081111 is up-regulated in NSCLC tissues and cell lines and is associated with advanced TNM stage and lymph node metastasis. Functionally, it promotes NSCLC cell proliferation, invasion, EMT, and xenograft tumor growth. Mechanistically, cytoplasmic hsa_circ_0081111 binds the RBP IGF2BP2 to enhance Slug mRNA stability and increase Slug expression, suggesting diagnostic and therapeutic potential in NSCLC.
Confidence score:

0.8508
Other information
Title:

Hsa_circ_0081111 promotes the proliferation and metastasis of non-small cell lung cancer by regulating IGF2BP2-mediated stability of Slug mRNA.

Journal: Experimental cell research
Published: 2025
PubMed ID: 40712910
Study type:

combined biological and clinical study
Data availability: GSE236879; TCGA; GEPIA 2; Supplementary data at https://doi.org/10.1016/j.yexcr.2025.114685
Code availability: -