| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-1184, hsa-miR-383, hsa-miR-766 |
| Biological function: |
Silencing hsa_circ_009755 promotes OSCC cell proliferation, migration and invasion and suppresses apoptosis, suggesting that hsa_circ_009755 acts as a tumor-suppressive circRNA in OSCC. |
| Molecular mechanism: |
Possible miRNA interaction mechanism predicted by CircInteractome; hsa_circ_009755 may interact with hsa-miR-1184, hsa-miR-383 and hsa-miR-766, but the mechanism was not experimentally validated. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_009755 may have diagnostic value as a biomarker for OSCC; ROC AUC was 0.83. |
| Description: |
hsa_circ_009755 is downregulated in OSCC tissues and cell lines. Functional assays indicate that hsa_circ_009755 suppresses OSCC cell proliferation, migration, invasion and metastasis-related behavior while promoting apoptosis. The study suggests hsa_circ_009755 may serve as a diagnostic biomarker, with predicted interactions with hsa-miR-1184, hsa-miR-383 and hsa-miR-766. |
| Confidence score: |
0.6474 |