circRNA basic information
circBase ID: hsa_circ_0000566
Name: hsa_circ_VRK1
Synonym: -
Host Gene: VRK1
Genomic location(hg19): chr14:97299803-97327072:+
Genomic location(hg38): chr14:96833466-96860735:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0100096
MONDO name: COVID-19
Disease details: SARS-CoV-2 infection
Disease DO ID:
 0080600
Disease MeSH ID:
 D000086382
Disease NCIt ID:
 -
Disease ICD11 ID:
 1730556128
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

Calu-3; BEAS-2B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: AGO2, EIF4A3, HuR, U2AF65
Associated microRNA: -
Biological function: Potentially involved in regulating host antiviral transcriptional response during SARS-CoV-2 infection.
Molecular mechanism: Predicted to act as protein sponge for RBPs (e.g., AGO2, EIF4A3, HuR, U2AF65); ceRNA mechanism discussed at study level but not specified for this circRNA.
Biological pathway or process:

immune regulation (other); inflammation (other); ceRNA regulation (other); mRNA stability (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0000566 is a SARS-CoV-2 infection-associated dysregulated host circRNA validated by RT-qPCR in BEAS-2B cells after RNA-seq discovery in Calu-3. It is predicted to bind RBPs including AGO2, EIF4A3, HuR and U2AF65, suggesting potential involvement in post-transcriptional regulation during antiviral responses.
Confidence score:

0.4032
Other information
Title:

Differential host circRNA expression profiles in human lung epithelial cells infected with SARS-CoV-2.

Journal: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Published: 2021
PubMed ID: 34004360
Study type:

combined biological and bioinformatics study
Data availability: PRJCA002617; https://doi.org/10.1016/j.meegid.2021.104923
Code availability: -