| Expression pattern: |
UP |
| Associated gene: |
Yes-associated protein 1 (YAP1) |
| Associated microRNA: |
miR-141-3p, miR-200a-3p |
| Biological function: |
promotes proliferation, migration, and invasion; promotes EMT progression in endometriosis in vitro |
| Molecular mechanism: |
circATRNL1 acts as a ceRNA to sponge miR-141-3p and miR-200a-3p, thereby upregulating YAP1 and promoting EMT |
| Biological pathway or process: |
EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; IHC (Immunohistochemistry); Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circATRNL1 is up-regulated in ectopic endometriotic tissues and mainly localizes to the cytoplasm in Ishikawa cells. It promotes proliferation, migration, invasion and EMT by acting as a ceRNA that sponges miR-141-3p and miR-200a-3p to upregulate YAP1 in vitro. |
| Confidence score: |
0.7325 |