| Expression pattern: |
UP |
| Associated gene: |
BCL2L2 |
| Associated microRNA: |
miR-216a-5p |
| Biological function: |
Promotes OSCC cell proliferation, migration and invasion and inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-216a-5p to post-transcriptionally regulate BCL2L2. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0011946 is up-regulated in OSCC tissues and cell lines and predominantly localizes to the cytoplasm. It promotes malignant phenotypes by sponging miR-216a-5p to relieve repression of BCL2L2, thereby enhancing proliferation/migration/invasion and reducing apoptosis; its knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.8442 |