circRNA basic information
circBase ID: hsa_circ_0018289
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr10:46968580-46969453:-
Genomic location(hg38): chr10:46580164-46581035:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; paired adjacent tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: unknown
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis
Clinical significance:

Circ_0018289 could clearly separate tumor tissue from adjacent tissue (AUC 0.907) and high tumor circ_0018289 expression was associated with worse DFS and OS; it independently predicted worse DFS.
Description:

In this prospective cohort of cervical cancer patients, circ_0018289 was up-regulated in tumor tissue versus paired adjacent tissue by RT-qPCR. High tumor circ_0018289 expression was associated with more advanced clinicopathologic features and predicted worse DFS/OS, and it independently predicted worse DFS.
Confidence score:

0.5918
Other information
Title:

A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289.

Journal: Journal of clinical laboratory analysis
Published: 2020
PubMed ID: 32320103
Study type:

clinical study
Data availability: -
Code availability: -