| Expression pattern: |
UP |
| Associated gene: |
CORO1C |
| Associated microRNA: |
miR-136-5p |
| Biological function: |
promotes docetaxel resistance and colony formation; inhibits apoptosis; promotes tumor growth; reduces docetaxel sensitivity |
| Molecular mechanism: |
acts as a miR-136-5p sponge to modulate CORO1C expression (ceRNA mechanism) |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model |
| Clinical significance: |
circ_0003998 expression was associated with NSCLC resistance to docetaxel (DTX) and was associated with tumor TNM stage, tumor metastasis and lymph node metastasis |
| Description: |
circ_0003998 is up-regulated in NSCLC, especially in docetaxel-resistant tissues/cells, and promotes chemoresistance, colony formation and tumor growth while inhibiting apoptosis. It functions as a ceRNA by sponging miR-136-5p to increase CORO1C expression, thereby reducing docetaxel sensitivity. |
| Confidence score: |
0.6825 |