circRNA basic information
circBase ID: hsa_circ_0007580
Name: -
Synonym: circRNA_102179
Host Gene: -
Genomic location(hg19): chr17:64728805-64738878:+
Genomic location(hg38): chr17:66732687-66742760:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC cancer tissue; tissue adjacent to cancer; pericarcinomatous tissues; tumor tissues
Cell lines:

CALU3; CALU6; A549; H1229; HBE
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: HMGB3, Ago2
Associated microRNA: miR-330-5p
Biological function: promotes NSCLC cell proliferation, colony formation, migration, invasion, and in vivo tumor growth
Molecular mechanism: circRNA_102179 acts as a miR-330-5p sponge and positively regulates HMGB3 expression through the miR-330-5p/HMGB3 axis
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

circRNA_102179 may be a potential biomarker and therapeutic target for NSCLC
Description:

circRNA_102179/hsa_circ_0007580 is up-regulated in NSCLC tissues and cell lines. It promotes NSCLC cell proliferation, colony formation, migration, invasion, and xenograft tumor growth, mainly by sponging miR-330-5p and positively regulating HMGB3 expression. The study suggests circRNA_102179 may serve as a potential biomarker and therapeutic target for NSCLC.
Confidence score:

0.7674
Other information
Title:

CircRNA_102179 promotes the proliferation, migration and invasion in non-small cell lung cancer cells by regulating miR-330-5p/HMGB3 axis.

Journal: Pathology, research and practice
Published: 2020
PubMed ID: 32911346
Study type:

combined biological and clinical study
Data availability: GSE112214; doi:https://doi.org/10.1016/j.prp.2020.153144
Code availability: -