circRNA basic information
circBase ID: hsa_circ_0067301
Name: hsa_circ_PLXND1
Synonym: hsa_circRNA_103470
Host Gene: PLXND1
Genomic location(hg19): chr3:129280642-129280746:-
Genomic location(hg38): chr3:129561799-129561903:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006515
MONDO name: acute pancreatitis
Disease details: acute pancreatitis
Disease DO ID:
 2913
Disease MeSH ID:
 -
Disease NCIt ID:
 C95437
Disease ICD11 ID:
 698285441
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

whole blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: May be involved in acute pancreatitis development and serves as a blood diagnostic biomarker; increases with disease severity and declines after treatment.
Molecular mechanism: ceRNA network constructed for this circRNA (miRNA binding predicted; specific miRNAs not detailed for this circRNA in text).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Can be used as a blood biomarker to diagnose acute pancreatitis at early stage; diagnostic performance assessed by ROC (AUC 0.770 in MAP vs healthy).
Description:

hsa_circRNA_103470 is up-regulated in whole blood of acute pancreatitis patients, increases with disease severity, and decreases after treatment. It has diagnostic value for early AP (ROC AUC reported) and was included in a constructed ceRNA network, though specific miRNA partners were not detailed for this circRNA in the text.
Confidence score:

0.5963
Other information
Title:

Elevated hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470 in the Human Blood: Novel Biomarkers to Early Diagnose Acute Pancreatitis.

Journal: BioMed research international
Published: 2020
PubMed ID: 32149089
Study type:

combined biological and clinical study
Data availability: included within the supplementary information file
Code availability: -