| Expression pattern: |
DN |
| Associated gene: |
ALX4 |
| Associated microRNA: |
miR-942-5p |
| Biological function: |
Circ_0001445 acts as a tumor suppressor in HCC; its overexpression represses cell cycle progression, migration, invasion, EMT, glycolysis and tumorigenesis in vivo. |
| Molecular mechanism: |
Circ_0001445 functions through a ceRNA-like mechanism by sponging miR-942-5p to promote ALX4 expression. |
| Biological pathway or process: |
cell cycle (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); glycolysis (inhibits); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Cell Cycle Assay; Transwell Assay; Western Blot; RNA Pull-Down; Luciferase Reporter Assay; In Vivo Animal Model |
| Clinical significance: |
circ_0001445 might provide a novel target for HCC therapy. |
| Description: |
Circ_0001445/circSMARCA5 is down-regulated in HCC tissues and cells and functions as a tumor suppressor. Its overexpression inhibits HCC cell cycle progression, migration, invasion, EMT, glycolysis and xenograft tumor growth, mainly by sponging miR-942-5p to increase ALX4 expression. The study suggests circ_0001445 as a potential therapeutic target for HCC. |
| Confidence score: |
0.7032 |