| Expression pattern: |
UP |
| Associated gene: |
KIF2A |
| Associated microRNA: |
miR-524-5p |
| Biological function: |
circHIPK3 knockdown facilitates TMZ sensitivity and apoptosis, and represses proliferation, migration, invasion, and metastasis in TMZ-resistant glioma cells. |
| Molecular mechanism: |
circHIPK3 acts as a sponge for miR-524-5p, thereby regulating KIF2A and the PI3K/AKT pathway to modulate TMZ resistance and cellular behaviors. |
| Biological pathway or process: |
PI3K/AKT (promotes); apoptosis (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); chemoresistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
CircHIPK3 may be a potential target for diagnosis and therapy of TMZ-resistant glioma and a favorable indicator to improve TMZ therapy. |
| Description: |
circHIPK3 is up-regulated in TMZ-resistant glioma tissues and cells. Its knockdown increases TMZ sensitivity and apoptosis while inhibiting proliferation, migration, invasion, and metastasis. Mechanistically, circHIPK3 sponges miR-524-5p to regulate KIF2A and activate the PI3K/AKT pathway, supporting its potential therapeutic relevance in TMZ-resistant glioma. |
| Confidence score: |
0.7164 |