| Expression pattern: |
UP |
| Associated gene: |
ENO1, AGO2, TNF-alpha, IL-1, IL-6 |
| Associated microRNA: |
miR-22-3p |
| Biological function: |
circZNF609 promotes inflammation factor expression and aggravates neuropathic pain progression; circZNF609 knockdown alleviates mechanical allodynia and thermal hyperalgesia in CCI rats. |
| Molecular mechanism: |
circZNF609 acts as a molecular sponge for miR-22-3p and regulates inflammation factor expression through the miR-22-3p/ENO1 axis in CCI rat models. |
| Biological pathway or process: |
inflammation (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; FISH / smFISH; Transfection; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circZNF609 is up-regulated in CCI rat spinal cord tissue and promotes neuropathic pain progression. Mechanistically, it sponges miR-22-3p, relieves repression of ENO1, and increases inflammatory factors including TNF-alpha, IL-1, and IL-6; circZNF609 knockdown alleviates mechanical allodynia and thermal hyperalgesia. |
| Confidence score: |
0.6716 |