skeletal muscle biopsies; spinal cord; frontal cortex
iPSC-derived motor neurons
genetically engineered animal model
not specified
RNA-seq; RNase R Treatment; RT-qPCR; divergent primers PCR; Clinical Sample Validation; In Vivo Animal Model; Bioinformatics Analysis
downregulated in ALS muscle and also reduced in ALS spinal cord
hsa_circ_0047886 is selectively downregulated in ALS skeletal muscle with unchanged linear counterpart ZCCHC2 mRNA, and is also reduced in ALS spinal cord. No mechanism was defined.
0.6521
Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.
combined biological and clinical study