| Expression pattern: |
UP |
| Associated gene: |
CENPF, ZWINT, OIP5, BUB1B, DEPDC1 |
| Associated microRNA: |
hsa-miR-512-5p, hsa-miR-4773, hsa-miR-3611, hsa-miR-4742-3p, hsa-miR-6887-3p |
| Biological function: |
May serve key roles in breast cancer epithelial-mesenchymal transition and may provide insight into pathogenetic mechanisms of breast cancer metastasis. |
| Molecular mechanism: |
Predicted ceRNA mechanism: hsa_circRNA_002082 may sponge miRNAs and regulate downstream mRNAs/hub genes in a circRNA-miRNA-mRNA network. |
| Biological pathway or process: |
ceRNA regulation (other); EMT (other); metastasis (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection |
| Clinical significance: |
May provide potential therapeutic targets for breast cancer metastasis. |
| Description: |
hsa_circRNA_002082 is up-regulated in breast cancer tissues and was retained after RT-qPCR validation. The study proposes that it may act as a ceRNA in an EMT-related circRNA-miRNA-mRNA network, potentially regulating hub genes including CENPF, ZWINT, OIP5, BUB1B and DEPDC1 through predicted miRNA interactions. |
| Confidence score: |
0.4997 |