| Expression pattern: |
UP |
| Associated gene: |
E2F3 / E2F transcription factor 3 |
| Associated microRNA: |
miR-145-5p |
| Biological function: |
Promotes osteosarcoma cell proliferation, colony formation, cell cycle progression, migration, invasion, and tumorigenesis; inhibits apoptosis. |
| Molecular mechanism: |
hsa_circ_0008934 acts as a miR-145-5p sponge to enhance E2F3 expression in osteosarcoma cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; circRNA-seq; RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Transfection; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; In Vivo Animal Model; TUNEL; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Potential regulatory axis for diagnosis and treatment of osteosarcoma; foundation for development of new antiosteosarcoma drugs. |
| Description: |
hsa_circ_0008934 is up-regulated in osteosarcoma cell lines and functions as an oncogenic circRNA. It promotes proliferation, cell-cycle progression, migration, invasion, and xenograft tumorigenesis while inhibiting apoptosis, mainly through a hsa_circ_0008934/miR-145-5p/E2F3 ceRNA axis. |
| Confidence score: |
0.7982 |